Biochemical characterization of theHelicobacter pyloriCag-type IV secretion system unique component CagU
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چکیده
منابع مشابه
Crystal structure of the type IV secretion system component CagX from Helicobacter pylori
Helicobacter pylori, a Gram-negative bacterial pathogen prevalent in the human population, is the causative agent of severe gastric diseases. An H. pylori type IV secretion (T4S) system encoded by the cytotoxin-associated gene pathogenicity island (cagPAI) is responsible for communication with host cells. As a component of the cagPAI T4S system core complex, CagX plays an important role in viru...
متن کاملPlasticity of Repetitive DNA Sequences within a Bacterial (Type IV) Secretion System Component
DNA rearrangement permits bacteria to regulate gene content and expression. In Helicobacter pylori, cagY, which contains an extraordinary number of direct DNA repeats, encodes a surface-exposed subunit of a (type IV) bacterial secretory system. Examining potential DNA rearrangements involving the cagY repeats indicated that recombination events invariably yield in-frame open reading frames, pro...
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6 Carola Martínez-Núñez, Pamela Altamirano-Silva, Francisco Alvarado7 Guillén, Edgardo Moreno, Caterina Guzmán-Verri and Esteban Chaves8 Olarte 9 Programa de Investigación en Enfermedades Tropicales (PIET), Escuela de 10 Medicina Veterinaria, Universidad Nacional, 304-3000 Heredia, Costa Rica; 11 Escuela de Biología, Universidad Nacional, 304-3000 Heredia, Costa Rica; 12 Facultad de Farmacia, U...
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Unveiling molecular scaffolds of the type IV secretion system.
متن کاملStructure of a type IV secretion system core complex.
Type IV secretion systems (T4SSs) are important virulence factors used by Gram-negative bacterial pathogens to inject effectors into host cells or to spread plasmids harboring antibiotic resistance genes. We report the 15 angstrom resolution cryo-electron microscopy structure of the core complex of a T4SS. The core complex is composed of three proteins, each present in 14 copies and forming a a...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2017
ISSN: 0014-5793
DOI: 10.1002/1873-3468.12564